e principle eme of is EMBO Workshop is to bring toge er leading international experts, early career scientists, and postdoral and graduate scholars under one umbrella to discuss e latest developments in e emerging area of nuclear mechano-genomics and diseases. is EMBO Workshop will cover four major emes. is workshop will bring toge er scientists working in e membrane fusion events occurring in ree broad categories: 1 - intracellular (fusion of vesicles, fusion of mitochondria, fusion of inner and outer nuclear membranes to make a fusion pore). 2 -extracellular fusion between cells. 3 - fusion of enveloped viruses wi e membrane of. Welcome to e next EMBO conference on Nuclear Receptors: structure and function in heal and disease , to be held at e beautifully located Grand Hotel Gardone Riviera, from 2 rough 5,2007. is conference series takes place in alternating years wi e Keystone Meeting on Nuclear Receptors and provides a e conference will. e European Molecular Biology Organization (EMBO) invites all interested researchers to a workshop organized by Professor Susanne Mandrup, University of Sou ern Den k, on nuclear receptors and biological networks taking place 11-13 in Kolymbary, Crete, Greece. ABOUT E WORKSHOP. E workshop on Nuclear Receptors and Biological Networks continues e very successful EMBO . e venue of e meeting is e Domaine de Mousquety a resort in Sou ern France located on a beautiful park wi a 19 century castle in e village of L’Isle de la Sorgue, close to Avignon. It is an ideal site to welcome around 200 participants. In addition to enjoying e science, you will also appreciate e chance for informal discussion in a friendly and comfortable. is EMBO Workshop will bring toge er experts working at e interfaces between structural biology, biophysics and neurobiology. Particular focus is placed on processes at happen at or close to e cell membrane, where information is transduced by sophisticated mechanisms such as receptor-ligand interactions and channel properties. is EMBO workshop series has become e key international meeting for scientists investigating basic biological questions in regeneration and repair using a whole animal or organ systems approach. It brings toge er scientists wi diverse expertise using various models, from invertebrates to mammals, who not normally cross pa s. 02, · Aberrant expression of nuclear matrix‐associated proteins (NMPs) has been shown to associate wi tumor grow in various human cancers. is study shows at SATB2, a key NMP, and its coactivator CBP critically contribute to glioblastoma (GBM) grow, suggesting SATB2/CBP is a erapeutic target. is workshop is e ird in a series of EMBO meetings and represents e continuation of e signal transduction Dubrovnik meetings which started in 1998 and held every two years in e same venue, e beautiful Hotel Croatia in Cavtat, close to e town of Dubrovnik. In we will celebrate e 20 anniversary of is meeting, which has. 07, · During excitotoxicity, e neuroprotective peptide MTFL457 stabilizes e BDNF receptor TrkB‐FL. In a severe model of permanent brain ischemia (acute stroke), MTFL457 reduces infarct size and neurological damage, offering great potential for neurological conditions associated to excitotoxicity. 30, · In support of e EMBO Workshop on ‘Membrane shaping and remodelling by proteins in Xiu Ning, China on 11 - 14 April e EMBO Press editors have created a collection of recent articles on membrane dynamics in autophagy, endocytosis and cell division. 30, · EMBO Press is an editorially independent publishing platform for e development of EMBO scientific publications. identification of cis‐acting lncRNAs at regulate gene expression in response to infection identify a Toll‐like receptor‐induced upstream regulator of calcium An RNA‐binding protein coupling nuclear export and 3. Ligand binding induces conformational changes in nuclear receptors and promotes eir association wi a diverse group of nuclear proteins, including SRC-1/p160, TIF-2/GRIP-1 and CBP/p300 which. Isolation of genes encoding e receptors for steroids, retinoids, vitamin D, and yroid hormone and eir structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. is discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of ese orphan receptors and, in particular, of. receptor, 30 or more nuclear receptors had been identiﬁed (revie wed in ). ese included a drosophila receptor for ecdysone, an insect hormone at orchestrates. 14, · is mon 's cover highlights e article Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis by Jia-Rong Fan, Hong-Chen Chen and colleagues. e image shows pri y cilia in human retina pigment epi elial cells. e cells were serum-starved for 48 h to induce cilia formation and en stained for acetylated tubulin (white), pericentrin (green), F-actin (red). 16, · Transposon silencing requires e histone me yltransferase SETDB1. In is issue of EMBO Reports, Tsusaka et al  and Osumi et al  illustrate how e cofactor ATF7IP and its fly homolog Windei (Wde) regulate e me yltransferase function of SETDB1 rough its nuclear licensing. e new insight gained from ese two articles will shift how we ink about epigenetic regulation and . Nuclear receptors (NRs) are transcription factors at orchestrate complex regulatory networks in many biological processes, including cell proliferation, metabolism, immunity, and development . e human NR superfamily, which consists o 8 members, includes receptors for steroid hormones, yroid hormones, retinoic acid, vitamin D, fatty acids, and cholesterol metabolites (oxysterols) . Nuclear Hormone Receptors (NHRs) are ligand-activated transcription factors at, in concert wi additional factors, regulate gene expression or repression and play a critical role in endocrine signaling. For discovery of el compounds targeting NHRs, DiscoverX offers 26 cell-based assays wi full-leng NHR, which are ideal for measuring. 01, 2006 · is EMBO Conference on ‘Nuclear Receptors: from Chromatin to Disease’ took place between 29 and 1 ober 2005, in Gardone Riviera, Italy, and was organized by. Maggi, J. Schwabe, D. Moore and T. Perlmann. Introduction Nuclear receptors are a family of transcription factors e activity of which is modulated by binding to small signalling molecules. ese compounds trigger. belonging to e nuclear receptor superfamily (Mangelsdorf et al., 1995). In addition to ese ligand-activated receptors, o er members of e family are structurally related proteins for which no ligand has yet been identified, and erefore are referred to as ‘orphan’ receptors. e retinoid-related orphan receptor . EMBL Heidelberg. Meyerhofstraße 1 69117 Heidelberg, Germany Tel: +49 6221 387-0 Fax: +49 6221 387-8306 Full contact details ›. Feb 27, · Report New Roles for Nuclear Receptors in Heal, Development & Disease Cancun, Feb 27 - ch 02nd . is new major meeting, focussing on recent break roughs and insights in Nuclear Receptor Biology, took place in Cancun, Mexico from Feb 27 to ch 2 nd . It had a broad remit, to cover how nuclear receptors shape development and contribute to heal as well as . Nuclear receptors (NRs) are important pharmaceutical targets because ey are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal role in modulating nuclear receptor activity, e discovery of el ligands for nuclear receptors represents an interesting and promising erapeutic approach. During e meeting on Nuclear Receptor Gene Family held at Incline Village, Nevada, ch 28 –April 3, 1998, e crystal structure of e LBD of hormone bound proges-. All nuclear receptors exhibit similar structural features (Figure 1 B).Nuclear receptor LBD structures contain 11–13 α-helices at are arranged into a ree-layer antiparallel α-helical sandwich [75,76]. e ree long helices (H3, 7, and ) form e two outer layers, and e middle layer of helices (H5, 6, 8, and 9) is present only in e top half of e domain, ereby creating a cavity. e Science Must Go On: Announcing eSymposia Virtual Meetings. Keystone Symposia is committed to continuing our strong tradition of bringing e scientific community toge er, across geographic and interdisciplinary boundaries, to catalyze e discovery, in ation, and break roughs at accelerate scientific research and medical advancement. 15, 2001 · e inner nuclear membrane is also ought to contain IP 3 /IP 4 receptors (reviewed in Rogue and Malviya, 1999), Ire1, a multifunctional protein involved in chaperoning (Sidrauski and Walter, 1997), and nurim, a recently identified protein of unknown function (Rolls et al., 1999). however, definitive morphological evidence supporting an. 27, · e isolation of e first complete steroid receptor cDNAs, e glucocorticoid and estrogen receptors, was transformative (Green et al., 1986, Hollenberg et al., 1985) .Comparison of e sequences revealed a conserved evolutionary template, and it also permitted e delineation of e structural and functional features at foreshadowed e emergence of a nuclear receptor superfamily. Estrogen receptor-α (ERα) is a ligand inducible transcription factor at belongs to e superfamily of nuclear receptors. Upon hormone binding, ERα is activated and regulates e transcription of target genes. Similar to o er nuclear receptors, ERα is divided into regions A rough F. e N-terminal A/B region harbors transactivation. 15, 2001 · e HMGB family: structure, expression and nuclear function. e HMGB family comprises e ree proteins HMGB1 (previously HMG1), HMGB2 (previously HMG2) and HMGB3 (previously HMG4 or HMG2b) (Bustin, 2001). e structure of ese ree proteins is highly conserved (80 amino acid identity), and eir biochemical properties are so far indistinguishable. REV-ERBα, a nuclear receptor involved in e circadian clockwork, has been shown to control lipid metabolism. To gain insight into e role of REV-ERBα in energy homeostasis in vivo, we explored daily metabolism of carbohydrates and lipids in chow-fed, unfed, or high-fat-fed Rev-erb α −/− mice and eir wild-type littermates. In addition to nuclear hormone receptor repression of inflammatory mediators, nuclear hormone receptors are capable of modulating innate immunity in a positive manner. Vitamin D activation of VDR results in e induction of antimicrobial peptides, including ca elicidin antimicrobial peptide and defensin β2, as well as e TLR4 coreceptor CD14. 02, 2003 · e NF-κB pa way. Nuclear factor-κB (NF-κB) is a critical regulator of e immediate early pa ogen response, playing an important role in promoting inflammation and in e regulation of cell proliferation and survival (Karin et al., 2002. Li and Verma, 2002).NF-κB is a collective term referring to a class of dimeric transcription factors belonging to e Rel family. Nuclear receptor structure and function. As a group, most nuclear receptors share a common, highly conserved domain structure (Fig. 1).At e amino-terminus, e activation function-1 (AF1) domain is a highly divergent region at assists in regulating e transcriptional activity of nuclear receptors independent from ligand binding (Ku and Litwack 2009). Nuclear receptors (NRs) are a family of ligand-regulated transcription factors at modulate a wide variety of physiological functions in a ligand-dependent manner. e first NRs were discovered as receptors of well-known hormones such as 17β-estradiol, corticosteroids, or yroid hormones. In ese cases a direct activation of e receptor. 2. e Nuclear Receptor Superfamily. Before e genes encoding ese receptors were cloned, e first member of e family to be identified biochemically was e estrogen receptor (ER) .About two ades after, e cDNA for e human glucocorticoid receptor (GR) was e first to be elucidated , followed by e ER  and e mineralocorticoid receptor (MR) . 01, 1999 · During e meeting on Nuclear Receptor Gene Family held at Incline Village, Nevada, ch 28–April 3, 1998, e crystal structure of e LBD of hormone bound progesterone receptor was discussed. e overall structure reveals at bo e pattern of folding and e corresponding regions involved in ligand contact are similar to homologous. is mini-review examines e crucial importance of transcription factors as a first line of defense in e detoxication of xenobiotics. Key transcription factors at recognize xenobiotics or xenobiotic-induced stress such as reactive oxygen species (ROS), include AhR, PXR, CAR, MTF, Nrf2, NF-κB, and AP-1. ese transcription factors constitute a significant portion of e pa ways induced. In vitro nuclear receptor binding experiments have shown at compared wi RU486, S-P has a two-fold lower affinity for e human glucocorticoid receptor. Fur ermore, in vitro cytoplasmic receptor binding experiments have shown at S-P, compared wi RU486, is 5.3-fold less potent as a PR antagonist, indicating greater GR selectivity an RU486. Feb 27, 2001 · Peroxisome proliferator-activated receptor α (PPARα) is a nuclear target for fatty acids, hypolipidemic drugs, and o er peroxisome proliferators (1–4) and initiates gene expression of enzymes involved in lipid metabolism (5, 6).Two fur er subtypes of is receptor exist, namely PPARβ and PPARγ, of which e latter is implicated to play a role in adipogenesis and adipocyte fatty acid. Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of ‘Type II autophagic cell dea ’ in 1990. However, is phenomenon later came into question, because e presence of autophagosomes in dying cells does not necessarily signify at autophagy is e cause of demise, but ra er reflect e efforts of e cell to prevent it. RU486 induced glucocorticoid receptor nuclear translocation in e pituitary, hippocampus and prefrontal cortex and glucocorticoid receptor-DNA binding in e hippocampus, whereas no effect of S-P on glucocorticoid receptor nuclear translocation or DNA . Watson CE, Archer TK. Chromatin and steroid-receptor-mediated transcription. in: Molecular Biology of Steroid and Nuclear Hormone Receptors. (Freedman, L.P. ed), Ch. 8, Pg. 209-35, Birkhser, Boston, 1998. Lee H-L, Archer TK. Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates e MMTV promoter. EMBO J. 17. e effects of RU486 and S-P, a more selective glucocorticoid receptor antagonist from Schering-Plough, were investigated on glucocorticoid receptor nuclear translocation and DNA binding. In e. Identification and localization of cis-acting regulatory elements wi in 2.3 kb of e 5′ flanking region of e human gonadotropin-releasing hormone receptor (hGnRHR) gene at are responsible for e basal and gonadotrope specific expression [Abstract]. 80 Annual Meeting of e Endocrine Society, New Orleans, Louisiana. 1998. 129-129. e nuclear receptor gene family includes 18 members at are broadly conserved among multiple disparate animal phyla, indicating at ey trace eir evolutionary origins to e time at which animal life arose. Typical nuclear receptors contain two major domains: a DNA-binding domain and a C-terminal domain at bind a lipophilic hormone. In e absence of ligand, some members of nuclear receptor family such as corticosteroid receptors are pri ily located in e cytoplasm, and ey rapidly accumulate in e nucleus upon ligand-binding. O er members of e family such as e estrogen receptor are mostly nuclear. Regardless of eir pri y location, ese oligomeric proteins undergo a dynamic nuclear-cytoplasmic shuttling.